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Int J Physiol Pathophysiol Pharmacol 2013;5(3):177-183

Original Article
Role of Hepatocyte Paraffin 1 antigen in the course of colorectal car-cinogenesis

Riham M Abu-Zeid, Rola M Farid

Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Received May 29, 2013; Accepted July 31, 2013; Epub September 10, 2013; Published September 15, 2013

Abstract: Background: Few studies have reported the expression of Hepatocyte Paraffin 1 (Hep Par 1) in colorectal carcinomas with
contra-dictory results. Reported rate of expression ranged from 4-50%. Moreover, the correlation between Hep Par 1 expression and
clinicopatholog-ical parameters has not been investigated. The objective of the present study was to investigate the role of CPS1 (using
Hep Par 1) in colonic carcinogenesis and characterize carcinomas which express it. Material and Method: Comparative analysis was
done between Hep Par 1 expression in normal colonic mucosa (n=10), adenomatous polyps (n=29) and sporadic adenocarcinoma
(n=40) and was correlated with clinicopathologic parameters. Results: Normal colonic mucosa did not express Hep Par 1. In contrast,
it was expressed in dysplastic glands and neoplastic cells of well-moderately differentiated non-mucinous adenocarcinomas. Hep Par
1 was found in 47.5% of colonic carcinomas, 41.7% of polyps with high grade dysplasia (HGD) and 23.5% of polyps with low grade
dysplasia (LGD). Mean Hep Par-1 score, likewise, was highest in carcinoma, high in polyps with HGD and lowest in polyps with LGD.
Hep Par 1 expression inversely correlated with some conventional prognostic parameters including tumour type, grade, lymph node
metastasis and AJCC stage. It did not correlate with depth of invasion or lymphovascular invasion. Conclusion: Hep Par 1 (i.e. CPS1)
might play an active role in initiation of dysplasia and progression of multistep colorectal carcinogenesis. However, it seems that CPS1
is not involved in invasion and tumour spread. Conversely, it might be in the play of suppressing cancer progression. These findings
could have both prognostic and therapeutic applications. (IJPPP1305004).

Keywords: Adenomatous polyp, colonic carcinoma, Hep Par 1, progression

Address correspondence to: Dr. Riham M Abu-Zeid, Department of Pathology, Faculty of Medicine, Ain Shams University, Abbasseya
Square, Cairo, Egypt, Postal Code 1156. Tel: 0020100 5330263; E-mail: riham_abuzeid@med.asu.edu.eg; riham_abuzeid@yahoo.com