Int J Physiol Pathophysiol Pharmacol 2010;3(1):29-37.
Original Article Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic activity in the rat detrusor
Ivy Wen Jia Teong, Amy An Ru Ko, Minghao Li, Klaus Heese, Willmann Liang
School of Biological Sciences, College of Science, Nanyang Technological University, Singapore; Institute of Advanced Studies, Nanyang Technological University, Singapore.
Received October 22, 2010; accepted November 1, 2010; Epub November 5, 2010; Published January 1, 2011
Abstract: Gastrodia elata (Tianma) is a traditional Chinese herb with demonstrated vasodilatory effects. This pilot study examined the effects of Tianma treatment on bladder smooth muscle contractility. Rats were treated with 2.5 g Tianma per kg body weight over 7 weeks. Contractility was measured in detrusor strips isolated in both transverse (Tr) and longitudinal (Lg) directions with the urothelium intact (+UE) or denuded (-UE). Spontaneous phasic activity was enhanced in longitudinal +UE strips. No differences between control and Tianma-treated detrusor strips were detected in contractions elicited by K+-Krebs’ solution or carbachol. Isoprenaline (IPNA)-induced relaxation remained unchanged in –UE strips after Tianma treatment. However, potency of IPNA was lower in Tianma-treated +UE strips in the longitudinal direction. These findings provided an initial assessment of how Tianma altered bladder smooth muscle function. It will be of interest in future investigations to elucidate the mechanisms via which Tianma exerts its actions on the bladder. (IJPPP1010001).
Address all correspondence to: Willmann Liang, PhD School of Biological Sciences College of Science Nanyang Technological University 60 Nanyang Drive Singapore 637551 Tel: +65-6316-2947 Fax: +65-6791-3856 Email: Willmann@ntu.edu.sg