IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2010;3(1):29-37.

Original Article
Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic
activity in the rat detrusor

Ivy Wen Jia Teong, Amy An Ru Ko, Minghao Li, Klaus Heese, Willmann Liang

School of Biological Sciences, College of Science, Nanyang Technological University, Singapore; Institute of Advanced Studies,
Nanyang Technological University, Singapore.

Received October 22, 2010; accepted November 1, 2010; Epub November 5, 2010; Published January 1, 2011

Abstract: Gastrodia elata (Tianma) is a traditional Chinese herb with demonstrated vasodilatory effects.  This pilot study examined the
effects of Tianma treatment on bladder smooth muscle contractility.  Rats were treated with 2.5 g Tianma per kg body weight over 7
weeks.  Contractility was measured in detrusor strips isolated in both transverse (Tr) and longitudinal (Lg) directions with the
urothelium intact (+UE) or denuded (-UE).  Spontaneous phasic activity was enhanced in longitudinal +UE strips.  No differences
between control and Tianma-treated detrusor strips were detected in contractions elicited by K+-Krebs’ solution or carbachol.  
Isoprenaline (IPNA)-induced relaxation remained unchanged in –UE strips after Tianma treatment.  However, potency of IPNA was
lower in Tianma-treated +UE strips in the longitudinal direction.  These findings provided an initial assessment of how Tianma altered
bladder smooth muscle function.  It will be of interest in future investigations to elucidate the mechanisms via which Tianma exerts its
actions on the bladder. (IJPPP1010001).

Key words: Gastrodia elata, Tianma, detrusor, urothelium, contraction, relaxation, phasic activity

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Address all correspondence to:
Willmann Liang, PhD
School of Biological Sciences
College of Science
Nanyang Technological University
60 Nanyang Drive
Singapore 637551
Tel: +65-6316-2947
Fax: +65-6791-3856
Email:
Willmann@ntu.edu.sg