IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2011;3(2):140-155.

Review Article
The roles of microRNAs in tumorigenesis and angiogenesis

Weining Yang, Daniel Y Lee, Yaacov Ben-David

Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada.

Received June 6, 2011; accepted June 11, 2011; Epub June 18, 2010; Published January 30, 2011

Abstract: MicroRNAs (miRNAs) are short, non-coding sequences that control gene expression via translational regulation. Through
interactions with the 3’-untranslated region of messenger RNA, miRNAs trigger translational repression and play a key role in
developmental timing. Furthermore, many miRNA groups have now been shown to regulate various processes in tumorigenesis,
including angiogenesis and metastasis. These links highlight the importance of microRNA research in further understanding cancer
development. This review article summarizes the current state of microRNA research, with a focus on the roles of microRNAs in various
cancer types. Up to date knowledge of the structure and biogenesis pathway of microRNA are also reviewed. (IJPPP1106001).

Keywords: microRNA, biogenesis, cancer, tumorigenesis, angiogenesis

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Address all correspondence to:
Weining Yang
Department of Medical Biophysics, Faculty of Medicine
University of Toronto S-Wing, Research Building
2075 Bayview Ave, Toronto
Ontario, Canada M4N 3M5.
Tel: 647-502-0524
E-mail:
weining.yang@utoronto.ca