Int J Physiol Pathophysiol Pharmacol 2011;3(2):140-155.
Review Article The roles of microRNAs in tumorigenesis and angiogenesis
Weining Yang, Daniel Y Lee, Yaacov Ben-David
Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada.
Received June 6, 2011; accepted June 11, 2011; Epub June 18, 2010; Published January 30, 2011
Abstract: MicroRNAs (miRNAs) are short, non-coding sequences that control gene expression via translational regulation. Through interactions with the 3’-untranslated region of messenger RNA, miRNAs trigger translational repression and play a key role in developmental timing. Furthermore, many miRNA groups have now been shown to regulate various processes in tumorigenesis, including angiogenesis and metastasis. These links highlight the importance of microRNA research in further understanding cancer development. This review article summarizes the current state of microRNA research, with a focus on the roles of microRNAs in various cancer types. Up to date knowledge of the structure and biogenesis pathway of microRNA are also reviewed. (IJPPP1106001).
Address all correspondence to: Weining Yang Department of Medical Biophysics, Faculty of Medicine University of Toronto S-Wing, Research Building 2075 Bayview Ave, Toronto Ontario, Canada M4N 3M5. Tel: 647-502-0524 E-mail: firstname.lastname@example.org