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Int J Physiol Pathophysiol Pharmacol 2011;3(2):156-166.

Review Article
The roles of microRNAs in tumorigenesis and angiogenesis

Minghua Li, Zhi-Gang Xiong

Department of Psychology, Washington State University, Vancouver, WA, USA. Neuroscience Institute, Morehouse
School of Medicine, Atlanta, GA, USA.

Received June 23, 2011; accepted June 26, 2011; Epub June 27, 2011; Published June 30, 2011

Abstract: Cancer is a leading cause of death in the world. Conventional treatments have severe side effects and low survival rate. It is
important to discover new targets and therapeutic strategies to improve the clinical outcomes of cancer patients. Ion channels are
specialized membrane proteins that play important roles in various physiological processes. Recent studies have shown that
abnormal expression and/or activity of a number of ion channels e.g. voltage-gated K+, Na+, Ca2+ channels, TRP channels, and
epithelial Na+/degenerin family of ion channels, are involved in the growth/proliferation, migration and/or invasion of cancer cells. In this
review, we summarize the present knowledge about the roles of different ion channels in the development of cancer(IJPPP1106003).

Keywords: Ion channels, cancer, therapeutic targets, voltage-gated K+, Na+, Ca2+ channels, TRP channels, and
epithelial Na+/degenerin family of ion channels

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Address all correspondence to:
Minghua Li, PhD
Department of Psychology, Washington State University
Vancouver, WA, USA. E-mail: Minghua.li@ vancouver.
wsu.edu;

Zhi-Gang Xiong, MD, PhD, Neuroscience
Institute, Morehouse School of Medicine,
Atlanta, GA, USA. E-mail: zxiong@msm.edu