IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2011;3(4):243-248.

Original Article
Interactions between synchrotron radiation X-ray and biological tissues ---
theoretical and clinical significance

Heyu Chen, Xin He, Caibin Sheng, Yingxin Ma, Hui Nie, Weiliang Xia, Weihai Ying

School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, P.R. China

Received July 17, 2011; accepted September 20, 2011; Epub October 11, 2011; Published December 15, 2011

Abstract: Synchrotron radiation (SR) X-ray has great potential for its applications in both diagnosis and treatment of diseases, due to
its characteristic properties including coherence, collimation, monochromaticity, and exceptional brightness.  Great advances have
been made regarding potential medical applications of SR X-ray in recent years, particularly with the development of the third
generation of SR light sources.  However, multiple studies have also suggested damaging effects of SR X-ray on biological samples
ranging from protein crystals to cells and biological tissues.  It has become increasingly important to conduct comprehensive studies
on two closely related topics regarding SR X-ray in medical applications:  The safety issues regarding the medical applications of SR
X-ray and the fundamental mechanisms underlying the interactions between SR X-ray and biological tissues.  In this article, we
attempted to provide an overview of the literatures regarding these two increasingly significant topics.  We also proposed our
hypothesis that there are significant differences between the biological tissue-damaging mechanisms of SR X-ray and those of normal
X-ray, due to the characteristic properties of SR X-ray such as high dose rate.  Future studies are warranted to test this hypothesis,
which may profoundly improve our understanding regarding the fundamental mechanisms underlying the interactions between light
and matter.  These studies would also constitute an essential basis for establishing the safety standard for the medical applications of
SR X-ray. (IJPPP1107003).

Keywords: Synchrotron radiation, X-ray, tissue damage, ROS, radiation safety  

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Address all correspondence to:
Weihai Ying, PhD
School of Biomedical Engineering and Med-X Research Institute
Shanghai Jiao Tong University
1954 Huashan Road, Shanghai, 200030
P.R. China.
Tel: 011-86-21-6293-3075; Fax: 011-86-21-6293-2302
E-mail: weihaiy@sjtu.edu.cn