IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2012;4(1):28-35.

Review Article
The link between angiotensin II-mediated anxiety and mood disorders with NADPH
oxidase-induced oxidative stress

Feng Liu, Jennifer Havens, Qi Yu, Gang Wang, Robin L. Davisson, Virginia M Pickel, Costantino Iadecola

Department of Child & Adolescent Psychiatry, New York University-Bellevue Hospital Center, New York, NY 10016, USA; Department of
Neurology & Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA; Department of Biomedical Sciences, College of
Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA

Received December 29, 2011; accepted January 22, 2012; Epub February 15, 2012; Published March 15, 2012

Abstract: The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in
hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in
the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent
advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may
underlie pathogenesis of mood and anxiety disorders. (IJPPP1112002).

Keywords: Renin-angiotensin system, angiotensin II, anxiety disorder, bipolar disorder, major depressive disorder, reactive oxygen
species, NADPH oxidase

Address all correspondence to:
Dr. Feng Liu
Inpatient Child Psychiatric Unit, Bellevue Hospital Center
462 First Avenue, New York, NY 10016, USA.
Tel: 212-562-4504; E-mail: FENG.LIU@NYUMC.org ).

Or: Dr. Gang Wang
Division of Neurobiology, Weill Cornell Medical College
407 East 61st Street, Room-308, New York, NY 10065, USA.
Tel: 646-962-8273; Fax: 646-962-0535
E-mail: gaw2001@med.cornell.edu