IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2012;4(3):149-155

Review Article
Roles of caveolin-1 on anoikis resistance in non small cell lung cancer

Preedakorn Chunhacha, Pithi Chanvorachote

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, and Cell-based Drug and Health Products
Development Research Unit, Chulalongkorn, University Bangkok, 10330, Thailand

Received July 2, 2012; accepted August 20, 2012; Epub September 20, 2012; Published September 30, 2012

Abstract: Advance therapies which effectively reduce mortality in lung cancer patients become a global health challenge nowadays.
Sufficient knowledge regarding cellular and molecular basis of cancer progression and metastasis would possibly help in the
development of novel and effective strategies for the treatment of this disease. This review focuses on the information regarding the
role and mechanism of caveolin-1 (Cav-1) protein on anoikis in Non Small Cell Lung Cancer (NSCLC). NSCLC accounts of
approximately 80% of all diagnosed lung cancer cases which patients frequently presented with metastatic disease. Like other
cancers, caveolin-1 (Cav-1) has been shown to play an important role in regulating cancer-cells behaviors including apoptosis
resistance and metastasis. Even though further investigations as well as in vivo experiments are required, these data are of great
interest and may be beneficial to the development of lung cancer therapy. (IJPPP1207001).

Keywords: Caveolin-1 (Cav-1), anoikis resistance, Non Small Cell Lung Cancer (NSCLC), cancer therapy, apoptosis resistance,
metastasis


Address all correspondence to:
Dr. Pithi Chanvorachote
Department of Pharmacology and Physiology
Faculty of Pharmaceutical Sciences
Chulalongkorn University
Pathumwan, Bangkok, Thailand 10330.
E-mail: pithi_chan@yahoo.com; pithi.c@chula.ac.th