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Int J Physiol Pathophysiol Pharmacol 2013;5(2):120-127

Original Article
Inpatient antibiotics pharmacology and physiological use in Hayata-bad medical
complex, Pakistan

Salman Khan, Adeeb Shehzad, Omer Shehzad, Ebtesam A Al-Suhaimi

Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan; Department of Biology, College of Science, University of
Dam-mam, Dammam, Saudi Arabia; School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu,
South Korea; Department of pharmacy, Abdul wali khan university, Mardan, Pakistan

Received February 24, 2013; Accepted April 27, 2013; Epub May 27, 2013; Published June 15, 2013

Abstract: Antibiotics are used commonly and as powerful medicines, it well known that they affect the variety and composition of the
micro-flora which has important physiological roles, therefore and for other health complications, the aim of the current study was to
evaluate and estimate the appropriateness of antimicrobial drugs use in Hayatabad Medical Complex (HMC), Peshawar, Pakistan. The
present work is based on the hospitalized patient’s case studies. Individual patients were interviewed using the prepared
questionnaire for the study. All hospitalized patients who received antibiotics were evaluated by a cross-sectional study. The total
number of patients interviewed was 270 in medical department. According to our study in medical department, for prophylaxis 64.3% of
antibiotic was used, whereas, an empirical use was 35.7%. Prodigious double regimen of antibiotics was observed throughout the
study. The most prescribed antimicrobial group is penicillin and followed by tetracycline, macrolides, quinolones, and cephalosporin.
Furthermore, 14.56% antibiotics were prescribed on generic name and 85.43% were prescribed on the basis of brand names. Taken
together, the antibiotic use in medical department was unsatisfactory and irrational. In summary, in order to protect the physiological
functions of flora microorganisms, a combination of both limitation, continuous education of physicians and elaboration of local
guidelines appear to be necessary to improve rational antibiotic use. (IJPPP1302005).

Keywords: Irrational antibiotic use, rational use, drug resistance, empirical, prophylaxis

Address correspondence to: Salman Khan, Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan. E-mail: