IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2013;5(3):190-193

Brief Communication
Effects of a single low-dose acetaminophen on body temperature and running
performance in the heat: a pilot project

Martin Burtscher, Hannes Gatterer, Marc Philippe, Philipp Krüsmann, Stefanie Kernbeiss, Veronica Frontull, Philipp Kofler

Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria; Austrian Society for Mountain and High-
Altitude Medicine, Innsbruck, Austria; Centre of Technology of Ski and Alpine Sports, Innsbruck, Austria

Received July 10, 2013; Accepted August 20, 2013; Epub September 10, 2013; Published September 15, 2013

Abstract: Purpose: To examine the effects of a single low-dose (500 mg) acetaminophen on body temperature and running
performance in the heat (30 °C). Methods: This is a randomized, cross-over pilot study performed in a climatic chamber at the
Department of Sport Science of the University of Innsbruck. Seven male sport students (age, 25.9 ± 2.3 years; V̇O2max, 67.3 ± 7.1
mL/min/kg) participated in the study. Each participant performed two prolonged exercise tests at a constant intensity on a treadmill at a
temperature of 30 °C at an individual intensity corresponding to 70 % VO2max. Two hours before exercising participants were randomly
assigned to receive acetaminophen (500 mg) or placebo and performed the same test 2 weeks later with reverse pre-treatment.
Results: After 20 min of running in the heat core temperature increase was less under acetaminophen (P = 0.004) and heart rates were
higher (P = 0.02) compared to placebo. At the end of exercise neither running time nor body temperature nor ratings of perceived
exertion differed between groups. Conclusion: Although the increase in core temperature was slightly reduced by acetaminophen after
20 minutes of running in the heat running performance remained unaffected after pre-treatment with a single low-dose of
acetaminophen. (IJPPP1307003).

Keywords: Acetaminophen, heat, running, performance, thermoregulation

Address correspondence to: Dr. Martin Burtscher, Department of Sport Science, Medical Section, University Innsbruck, Fürstenweg
185, 6020 Innsbruck, Austria. E-mail: martin.burtscher@uibk.ac.at