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Int J Physiol Pathophysiol Pharmacol 2013;5(3):184-189

Brief Communication
ERK1/2 in the brain mediates the effects of central resistin on reducing
thermogenesis in brown adipose tissue

Samin Kosari, Donny M Camera, John A Hawley, Martin Stebbing, Emilio Badoer

School of Medical Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Australia. Authors contributed
equally to this study.

Received July 15, 2013; Accepted August 23, 2013; Epub September 10, 2013; Published September 15, 2013

Abstract: We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7
µg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was
significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 µg) (P < 0.05). Resistin reduced uncoupling protein-1
mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated
receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain
contributes to resistin’s effects on thermogenesis. (IJPPP1307004).

Keywords: Resistin, brown adipose tissue, thermogenesis, ERK1/2

Address correspondence to: Dr. Emilio Badoer, Neuropharmacology and Neuroinflammatory Research Group, School of Medical
Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia. Tel: +61 (3) 9925 7081; Fax: +61 (3) 9925 7063; E-mail: