Int J Physiol Pathophysiol Pharmacol 2009;1(2):150-153.
Short Communication Effect of trifluoperazine on carrageenan-induced acute inflammation in intact and adrenalectomized rats
Mehdi Mahmoodi, Mohammad Khaksari Hadad, Ali Shamsizadeh, Afrooz Azarang, Reza Abbasi Rayeni
Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Physiology Research Centre, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Received February 24, 2009; accepted March 10, 2009; available online March 15, 2009
Abstract: The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat’s paw edema in intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of Evans blue dye as inflammatory indicators. In both ADX and control groups, administration of TFP reduced inflammatory parameters (paw volume and tissue content of Evans blue dye) in inflamed paw. Our findings suggest that TFP can effectively reduce carrageenan- induced paw edema in both ADX and control rats. Therefore, anti-inflammatory effect of these drugs does not need the adrenal gland activity. (IJPPP902008).
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