IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2009;1(2):150-153.

Short Communication
Effect of trifluoperazine on carrageenan-induced acute inflammation in intact and
adrenalectomized rats

Mehdi Mahmoodi, Mohammad Khaksari Hadad, Ali Shamsizadeh, Afrooz Azarang, Reza Abbasi Rayeni

Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Physiology Research
Centre, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology, Faculty of Medicine, Rafsanjan University of
Medical Sciences, Rafsanjan, Iran.

Received February 24, 2009; accepted March 10, 2009; available online March 15, 2009

Abstract: The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat’s paw edema in
intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of
0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of
Evans blue dye as inflammatory indicators. In both ADX and control groups, administration of TFP reduced inflammatory parameters
(paw volume and tissue content of Evans blue dye) in inflamed paw. Our findings suggest that TFP can effectively reduce carrageenan-
induced paw edema in both ADX and control rats. Therefore, anti-inflammatory effect of these drugs does not need the adrenal gland
activity. (IJPPP902008).

Key words: Paw edema, trifluoperazine, adrenalectomy, carrageenan, inflammation

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Address all correspondence to:
Ali Shamsizadeh, PhD
Department Of Physiology
Faculty of Medicine
Rafsanjan University of Medical Sciences
Rafsanjan, Iran
Tel: +98(0)391523 4003 Fax: +98(0)3915225209
E-mail: ashamsi@rums.ac.ir or alishamsy@gmail.com