IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2009;1(2):154-16.

Review Article
Effect of Escitalopram on GABA level and anti-oxidant markers in prefrontal cortex
and nucleus accumbens of chronic mild stress-exposed albino rats

Amany shalaby, Sahar kamal

Clinical Pharmacology, Faculty of medicine, Mansoura university, Egypt

Received April 21, 2009; accepted June 13, 2009; available online June 20, 2009

Abstract: Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression.
Antidepressants are widely prescribed to treat these conditions; however, few animal studies have investigated the effect of these
drugs on endogenous antioxidant status in the brain. The present study employed a 3 weeks chronic regimen of random exposure to
chronic mild stress (CMS)  to induce oxidative stress in brain, and behavioural aberrations (anhedonia), in rats. The sucrose
preference test was used to identify depression-like phenotypes, and reversal in these indices indicated the effectiveness of treatment
with escitalopram 2.5mg/kg daily orally following CMS. The level of superoxide dismutase enzyme(SOD) as an antioxidant markers in
erythrocyte lysates was reduced in CMS control group while it was elevated in CMS group treated with escitalopram.Also escitalopram
significantly reduce the thiobarbituric acid reactive substance(TBARS) levels in selected brain areas homogenates to a level
comparable to control group. Catalase activity and GABA levels in these brain areas were also increase in escitlopram treated group. In
conclusion, escitalopram is suggested to have antioxidant effect associated with an increase in GABA level in frontal cortices and
nucleus accumbens homogenates from rats exposed to CMS.(IJPPP904001).

Key words: Escitalopram, chronic mild stress, antioxidant effect, SOD,GABA levels

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Address all correspondence to:
Amany Shalaby, PhD
Clinical Pharmacology
Faculty of medicine
Mansoura university, Egypt