IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2009;1(2):162-179.

Review Article
Methamphetamine abuse, HIV infection, and neurotoxicity

Benjamin C. Reiner, James P. Keblesh, Huangui Xiong

Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center,
Omaha, Nebraska, USA

Received September 1, 2009; accepted September 21, 2009; available online September 25, 2009

Abstract: Methamphetamine (Meth) use and human immunodeficiency virus (HIV) infection are major public health problems in the
world today. Ample evidence indicates that HIV transfection risk is greatly enhanced with Meth use. Studies have shown that both HIV
infection and Meth abuse can cause neuronal injury leading to neurodegeneration. While many studies have focused on the individual
effects of Meth and HIV on the brain, few investigations have been carried out on their co-morbid effect in the nervous system. In this
review, we try to summarize recent progress on individual effects of Meth and HIV on neurodegeneration and their potential underlying
mechanisms, in addition to exploring their co-morbid effect on the brain. (IJPPP909001).

Key words: HIV-1, AIDS, Methamphetamine, Neurotoxicity, Neurodegeneration

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Address all correspondence to:
Huangui Xiong, MD, PhD
Laboratory of Neurophysiology
Center for Neurovirology and Neurodegenerative Disorders
University of Nebraska Medical Center
Omaha, NE 68198, USA
Tel: (402) 559-5140, Fax: (402) 559-8922
Email:
hxiong@unmc.edu