IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2009;1(2):192-202.

Review Article
Notch signaling and neurogenesis in normal and stroke brain

Mei-Juan Xiao, Zhao Han, Bei Shao, Kunlin Jin

Division of Stroke Medicine and Department of Neurology, and Institute of Regenerative Medicine, the First Affiliate Hospital, Wenzhou
Medical College, Wenzhou, China; Buck Institute for Age Research, Novato, CA 94945, USA

Received October 21, 2009; accepted November 5, 2009; available online November 10, 2009

Abstract: Adult neuronal stem cells (NSCs) hold great promise for brain repair because of their unique location within the central
nervous system, their potential to proliferate and to differentiate into all major neural lineages, and their ability to functionally incorporate
into existing neuronal circuitry after stroke. Nevertheless, the ability to exploit these cells for therapeutic purposes is hampered by the
lack of knowledge about the signals that control the generation of a functional neuron from adult NSCs after stroke, particularly in the
aged brain. Therefore, to further define the regulatory mechanisms that underlie neurogenesis after stroke, it is critically important to
develop future NSC-based repair strategies. Notch signaling defines a fundamental pathway controlling cell fate acquisition. Studies
have shown that Notch signaling pathways play critical roles during the maintenance, proliferation, and differentiation of NSCs in the
developing brain. Recent evidence shows that Notch1 signaling is conserved in the regulation of adult neurogenesis. Here we
summarize current knowledge about the role of Notch signaling in the regulation of neurogenesis in the normal and stroke brain.

Key words: Neurogenesis, adult, Notch signaling, SVZ, stroke

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Address all correspondence to:
Kunlin Jin, MD, PhD,
Buck Institute for Age Research
8001 Redwood Blvd.
Novato, CA 94945, USA
Tel: 415-2092086, Fax: 415-2092230