IJPPP Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Physiol Pathophysiol Pharmacol 2010;2(1):57-63.

Original Article
Rapid ischemic tolerance induced by adenosine preconditioning results in Bcl-2
interacting mediator of cell death (Bim) degradation by the proteasome

Yogendrasinh B. Solanki, Rajendra V. Bhatt

Department of Pharmacology, L. M. College of Pharmacy, Nagrangpura, Ahmedabad-380 009 Gujarat, INDIA.

Received December 12, 2009, accepted December 20, 2009, available online January 1, 2010

Abstract: The present study investigated the effects of antioxidant vitamins along with atorvastatin and atorvastatinniacin combination
on diet-induced hypercholesterolemia in rats. High cholesterol diet produced a significant increase in the serum total cholesterol, LDL-
C, VLDL-C, TG, atherogenic index and decrease in HDL-C and HDL/LDL ratio. The lipid peroxidation and oxidative stress were
significantly high in the hyperlipidemic control group. Atorvastatin improved atherogenic index but not the HDL/LDL ratio whereas
atorvastatin-niacin combination improved both atherogenic index and HDL/LDL ratio. However, both atorvastatin and atorvastatin-niacin
did not affect antioxidant status significantly. Co-administration of vitamin-E and vitamin-C along with atorvastatin and atorvastatin
niacin have improved serum lipid profile, prevented lipid peroxidation and improved antioxidant status. Addition of β-carotene along with
lipid lowering drugs did not show additional benefits on serum lipid profile, lipid peroxidation and antioxidant status. Atorvastatin,
atorvastatin-niacin combination when added with anti-oxidant vitamins, increased reduced glutathione level but did not affect MDA level,
SOD and catalase activity in the liver tissue. Administration of both vitamin-E and vitamin-C along with atorvastatin-niacin therapy
produced a significant improvement in the lipid profile as well as antioxidant status. Addition of β-carotene along with atorvastatin-
niacinvitamin- E-vitamin-C combination improved lipid profile but improvement was not as marked as observed with atorvastatin-niacin-
vitamin-E-vitamin-C combination. The same beneficial effects of atorvastatin-niacin combination on lipid profile were not observed
when it was combined with anti-oxidant vitamins especially β-carotene. The prooxidant role of β-carotene may be responsible for this

Key words: Hypercholesterolemia, lipid peroxidation, antioxidants, vitamin-E, vitamin-C, atorvastatin

Full Text  PDF

Address all correspondence to:
Yogendrasinh B. Solanki, PhD
Department of Pharmacology, L. M. College of Pharmacy
Nagrangpura, Ahmedabad-380 009
Gujarat, INDIA.
Tel: +91-79-6302746, Fax: +91-79-6444865